Lung diseases and viral infections

Lung viral infections

H2S is a main human natural defence against infections of the airways from viruses. Studies on the Respiratory Sincitial Virus (RSV) and other paramyxovirus infections in airway epithelial cells showed that the early phase of the infection associates with reduced release and intracellular level of H2S. The inhibition of a H2S production further promoted viral replication whereas the application of H2S reduced pro-inflammatory mediators production and viral replication. These mechanisms were confirmed on an array of enveloped RNA viruses from Ortho-, Filo-, Flavi- and Bunyavirus families including all the influenza virus strains tested (H1N1, H3N2 and Brisbane strain). Accordingly, H2S modulation was proposed as an approach for broad spectrum antiviral treatments.

SARS-CoV-2, responsible for Covid 19 epidemic, is as well an encapsulated RNA virus and might respond to the same mechanisms. Indeed, in Covid 19 patients the serum concentration of H2S is higher in survivors compared to fatal cases and correlates with the level of IL-6 and with mortality. Several authors have proposed H2S as an opportunity for therapeutic inteventions in Covid 19 and a full explanation of the disease as consequence of viral-induced drop of H2S has been proposed. Briefly, H2S is able to keep open the KATP channels of leucocytes, which avoids endothelial adhesion and cytokine storm essential to viral replication and disease pathogenesis. The virus is able to block this mechanism allowing its own replication and multiple organ damages. Fertile women and younger people, enjoying better efficient H2S release, are better protected from the infection but genetic weaknesses may cause overt disease in any subjects.


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Dattilo M. Role of host defences in Covid 19 and treatments thereof. Mol Med 2020; 26:90.



Hydrogen sulfide (H2S) and host defences against viral infections of airways

(see: Dattilo M. Role of host defences in Covid 19 and treatments thereof. Mol Med 2020; 26:90.












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The same mechanisms above described, including the effect on KATP channels, is also responsible for bronchodilation and an hampered release is involved in the pathogenesis of asthma.

Indeed, the H2S producing enzymes CSE and CBS are well expressed in smooth muscle cells and endothelial cells of pulmonary blood vessels. Compared to unaffected subjects, asthma patients have decreased blood levels of H2S that further drop during asthmatic crisis. Experimental animal models demonstrate an abnormal metabolism of H2S in asthma with deficit of release associated to bronchospasm, airway remodeling and chronic inflammation, which can be improved by H2S donors.


Wang P et al. Hydrogen sulfide and asthma. Exp Physiol 96.9 pp 847–852.

Hatziefthimiou A & Stamatiou R. Role of hydrogen sulphide in airways. World J Respirol. Jul 28, 2015; 5(2): 152-159. block. Click the edit button to edit this text.